Polynucleotides in Brighton & Hove

What are polynucleotides?

Polynucleotides are chains of nucleotides, the building blocks of DNA. The polynucleotides used in aesthetic treatments are highly purified and derived from fish DNA. They are injected into the skin in tiny amounts, using a very fine needle.

They work differently from treatments that add volume. They are thought to support the skin's own repair processes, including the fibroblasts that make collagen. They may also have hydrating and antioxidant properties. In practice, that means polynucleotides may help improve skin quality, hydration, texture and the look of fine lines over a course of treatments. The changes are gradual and subtle rather than dramatic, and results vary from person to person.

Which polynucleotides do I use?

I use the Nucleofill range, made by the Italian company Promoitalia. Nucleofill is a CE-marked medical device range of polynucleotide gels. The range comes in increasing concentrations:

• Nucleofill Soft Plus: the lightest concentration in the range

• Nucleofill Medium: a mid-strength concentration

• Nucleofill Strong and Strong Plus: the highest concentrations (Strong Plus is a larger syringe)

There's no one-size-fits-all product for an area. Skin varies a lot between people, even in the same part of the face. At your consultation I look at the thickness and condition of your skin, your concerns and your goals, and then choose the product and strength I think suits you. I'll explain what I'm using and why.

Who might polynucleotides suit?

Polynucleotides may suit you if you would like to improve the quality of your skin rather than change the shape of your face. People often ask about them for:

• thin, crepey or tired-looking skin under the eyes

• dull, dehydrated skin or fine lines on the face

• loss of firmness or crepiness on the neck

• a gentle, gradual improvement rather than an obvious change

They are not right for everyone. I won't treat you if you are pregnant or breastfeeding, if you have a fish or seafood allergy, if you have an active skin infection or cold sore in the area, or if certain medical conditions or medicines make treatment unsuitable. Dark circles have many causes, including pigmentation, genetics and the shape of the bones around the eye. Not all of these respond to polynucleotides, and I'll tell you honestly if I don't think they will help.

Which areas can be treated?

The areas I most often treat with polynucleotides are:

• Under-eyes: where the skin is thinnest and often looks crepey or tired

• Face: usually the cheeks and mid to lower face, to support overall skin quality

• Neck: for crepey or less firm skin

For every area, I tailor the Nucleofill product and how it's placed to your skin, rather than following a fixed recipe. Hands are not currently part of my standard polynucleotide treatments. If you're interested, ask at your consultation. For the hands I may suggest Profhilo instead. You can see everything I provide on my treatments page.

What happens at your appointment?

1. Consultation. We talk through what bothers you, your medical history and what you'd like to achieve. I examine your skin, explain whether polynucleotides are a good fit, and cover the likely benefits, risks and alternatives. There's no pressure to go ahead on the day.

2. Preparation. Your skin is cleansed thoroughly. If you're worried about discomfort, ask about comfort options.

3. Treatment. I inject small amounts of Nucleofill into the skin using a very fine needle. I'll talk you through how long your appointment will take when you book.

4. Aftercare. You'll get clear written aftercare advice and my contact details, so you can get in touch if you have any concerns.

How many sessions will I need, and how long do results last?

Polynucleotides are given as a course. My usual starting point is a course of three sessions, 3 to 4 weeks apart. I may suggest more depending on your skin.

Any changes build gradually, usually over the weeks after your course rather than straight away. How long they last varies with age, skin type, sun exposure and lifestyle. Many people choose to review their skin with me around six to twelve months later and have a single maintenance session if it's helpful.

Is there any downtime, and what are the side effects?

Most people go back to their normal day straight afterwards, though you may prefer not to book anything important for a day or two. Common, usually short-lived effects include:

• small raised bumps where the product was placed, which usually settle within a day or so (under the eyes they can take a little longer)

• redness, tenderness and mild swelling

• bruising, which can take several days to fade

Less common risks include infection, an allergic reaction, and lumps that are slow to settle. I'll go through these with you before any treatment, and I'm available afterwards if anything worries you.

Why choose a doctor-led clinic for polynucleotides?

Any injectable treatment should be carried out by someone medically trained, in a clean clinical setting, who can recognise and manage problems if they happen. As a medical doctor, I assess your medical history and medicines properly, I use genuine products from reputable suppliers, and I personally manage your aftercare. If polynucleotides aren't the right choice for you, I'll say so.

How much do polynucleotides cost?

Prices for polynucleotides start from £250 per session for the under-eyes, face or neck. A course of three sessions for the face or under-eyes is £600.

Your exact price is always confirmed at your consultation, before any treatment. Prices can change, so please check the booking page, which always shows current prices.

About Dr Josh O'Hara

Dr Josh O'Hara is an award-winning medical doctor with 6 years experience working in the NHS, including at Royal Sussex County Hospital and Worthing Hospital. He trained at Barts and The London School of Medicine and Dentistry and is registered with the General Medical Council (GMC number 7753722); you can check his registration on the GMC register. He set up Dr O'Hara Aesthetics to offer careful, natural-looking, doctor-led treatments, with honest advice from your first consultation onwards.

How do I find the clinic?

The clinic is at 65 Sackville Road, Hove BN3 3WE. When you arrive, follow the signs for Jayen Clinic; the clinic room is inside.

Book your consultation

If you're curious about polynucleotides, a good first step is a free, no-obligation consultation. We'll talk about your skin and your goals, and whether polynucleotides, or something else, is right for you.

Book online with Dr O'Hara

If you're thinking about frown lines, forehead lines or crow's feet, you can also book one of my consultations for lines and wrinkles.

Polynucleotides: frequently asked questions

Do polynucleotide injections hurt?

Most people describe a scratching or stinging feeling. The needle is very fine. If you're worried about discomfort, ask about comfort options at your consultation.

When will I notice a difference?

Polynucleotides work gradually, so changes are usually noticed over the weeks after your course rather than immediately. Results vary from person to person.

Are polynucleotides the same as Profhilo or other skin boosters?

No. Profhilo and many other skin boosters are based on hyaluronic acid, which attracts water to the skin. Polynucleotides are a different ingredient that is thought to support the skin's own repair processes. Sometimes one suits better than the other, and I'll advise at your consultation. You can read more on my Profhilo page.

Can I have polynucleotides if I'm allergic to fish?

No. Nucleofill is derived from fish DNA, so I don't treat anyone with a fish or seafood allergy. Please tell me about any allergies at your consultation.

Are polynucleotides suitable for vegans?

Because they are derived from fish, polynucleotides are not vegan. If that matters to you, let's talk about alternatives.

What should I avoid after treatment?

For the first day or so, avoid make-up on the treated area, strenuous exercise, saunas and alcohol. Don't massage or press on any small bumps. Use a high-factor sunscreen every day; it helps protect your results and your skin.

Can I combine polynucleotides with other treatments?

Often, yes. Polynucleotides can sit alongside a good skincare routine, peels and other skin treatments. I'll suggest a sensible order and timing so your skin has time to settle between treatments.

Is Nucleofill approved for use in the UK?

Nucleofill is a CE-marked medical device. It should only be injected by a trained medical professional using genuine products from a reputable supplier